My grandpa is on a whole bunch of drugs already. One being Mirtazapine for his constant worry?

My grandpa is on a whole bunch of drugs already. One being Mirtazapine for his constant worry. A week ago his doctor gave him Budeprion XL to enhance the Mirtazapine. Immediately with in a couple days it had side effects and he called in the middle of the night not knowing where he was. 2 nights ago he called at 11:30 at night looking for my grandmother that passed 2 years ago and last night when we called saying we were coming over, he said he was getting ready for breakfast. We called his doctor yesterday and he suggested that he continue with his new medicine for a few weeks to see if it starts to help with his anxiety, but I feel this is much more important to get him off of it. We pulled the pills from his pill tray last night and feel it is doing more harm than good. Please tell me what your opinion is.