58 year old experiencing pressure and a heaviness in her legs?

My wife is 58. She has no known allergies to medications and does not take any daily. For years she has taken excedrin daily for body aches and sumatriptan for migraines(not daily). Early last week she stopped taking excedrin because of having a colonoscopy this week. She is taking tylenol arthritis until the procedure.
By last Wednesday she stated experiencing pressure and a heaviness in her legs so much so that its causing great discomfort for sleep and daily routine. We have googled online connections to PAD, MS, vein issues, blood clots, etc. and nothing seems to fit the bill. Her Mom was in her early 50s when she had mobility issues and was said to have had a vitamin B12 lacking, causing her leg issues. Fibromyalgia is a thought. Would bone cancer come on that sudden? A few weeks ago she had her annual with our doctor and had blood work done with no hints of this. Just came on with stopping excedrin for 10 days. Thanks (…)